Loading...
About Michael
Michael is a BRIA Fellow at Sloan Kettering Institute, studying the activation and regulation of inflammasomes which are the intracellular sensors of the innate immune system.
Prior to that, Michael was an EMBO Fellow at Cambridge, studying protein and RNA biochemistry. He did his PhD at MIT on synthetic phosphorus chemistry.
Research Areas
Redox is used by nature to regulate enzymatic activity, fight infection, transduce signals, and induce cell death. We are developing methods that enable us to study and manipulate biological redox with a focus on the innate immune system and programmed cell death. Alongside, we are developing oligonucleotide analogues for therapeutic and technological applications. Check out more details on these research areas below.
Publications
The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
