About Michael
Michael is a Postdoctoral Associate at the University of Cambridge, where he previously spent time as an EMBO Fellow. He uses chemical and molecular biology to answer questions about the role of mitochondria, redox, and innate immunity in human disease.
Prior to that, Michael was a BRIA Fellow at Sloan Kettering Institute where he worked on the activation of inflammasomes, which are intracellular sensors of the innate immune system.
Research Areas
Redox is used by nature to regulate enzymatic activity, fight infection, transduce signals, and induce cell death. We are developing methods that enable us to study and manipulate biological redox with a focus on the innate immune system and programmed cell death. Alongside, we are developing oligonucleotide analogues for therapeutic and technological applications. Check out more details on these research areas below.
Publications
The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
